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En usikkerhed ved et registerstudie som dette er dog, at det ikke kan blive helt klart, hvorvidt en faktor såsom smertestillende piller står bag hele den tilsyneladende effekt på blodpropper.Fra gammel tid har person anvendt udtræk fra opiumsvalmuen i smertebehandling og disse midler er baseret på naturlige opioider eller de er kunstigt fremst
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